Neoadjuvant Chemotherapy for Nasopharyngeal Carcinoma: Opportunities, Potential Hazards and Drawbacks
ثبت نشده
چکیده
To date, there have been four randomised clinical studies conducted on the use of neoadjuvant chemotherapy for nasopharyngeal carcinoma (NPC), with two of the four showing positive results (Table 1). The VUMCA I study showed a significant reduction in tumour recurrence or progression, with a reduction in both local relapse and distant metastases after chemotherapy. Recently, Ma et al also showed significant improvement in local control after neoadjuvant chemotherapy — 5 year local recurrence rates were 18% and 26% for the chemotherapy and the radiotherapy alone arms respectively. The ‘negative’ study by Chan et al can be criticised on the grounds of its having low power. Even the Asian-Oceanian Clinical Oncology Association study, which had negative findings overall, showed a significant improvement in local control with chemotherapy among patients with very large nodes, in an unplanned subgroup analysis.
منابع مشابه
Pretreatment Diffusion-Weighted MRI Can Predict the Response to Neoadjuvant Chemotherapy in Patients with Nasopharyngeal Carcinoma
PURPOSE To explore the potential of diffusion-weighted (DW) magnetic resonance imaging (MRI) using apparent diffusion coefficient (ADC) for predicting the response to neoadjuvant chemotherapy in nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS Ninety-two consecutive patients with NPC who underwent three cycles of neoadjuvant chemotherapy were retrospectively analyzed. DW and anatomical M...
متن کاملIntravoxel Incoherent Motion-Magnetic Resonance Imaging as an Early Predictor of Treatment Response to Neoadjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma: Erratum
متن کامل
Role of Chemotherapy in Stage II Nasopharyngeal Carcinoma Treated with Curative Radiotherapy
PURPOSE To define the role of neoadjuvant and concurrent chemotherapy in stage II nasopharyngeal carcinoma, we compared the treatment outcomes of patients treated with curative radiotherapy with or without chemotherapy. MATERIALS AND METHODS From 2004 to 2011, 138 patients with American Joint Committee on Cancer (AJCC) 2002 stage II nasopharyngeal carcinoma were treated with curative radiothe...
متن کاملEfficacy and safety of nimotuzumab with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma
We assessed the efficacy and safety of nimotuzumab plus neoadjuvant chemotherapy followed by concurrent chemoradiotherapy for Chinese patients with locoregionally advanced nasopharyngeal carcinoma. Clinical data from 210 nonmetastatic nasopharyngeal carcinoma patients diagnosed between May 2008 and April 2014 were retrospectively reviewed. All patients were initially treated with nimotuzumab pl...
متن کاملSignificant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials.
BACKGROUND We carried out this meta-analysis to demonstrate efficacies of neoadjuvant chemotherapy (NACT) and adjuvant chemotherapy (AC) for nasopharyngeal carcinoma (NPC) patients based on randomized, controlled trials (RCTs). PATIENTS AND METHODS We comprehensively searched electronic databases and manuscripts for RCTs and extracted data from eligible studies for meta-analysis. Overall surv...
متن کامل